Solvent Free Synthesis of Some 4-OXO-Thiazolidine Derivatives of Phenothiazine | Original Article

ABSTRACT:

A new series of N-[2-(10H-phenothiazinyl) ethyl]-2-(substituted phenyl)-4-oxo-5-[(substituted phenyl) methylidene]-1-iminothiazolidine, compounds 5(a-m)have been synthesized. by microwave method. The cycloaddition reaction of thioglycolic acid with N-[2-(10Hphenothiazinyl) ethyl]-N’-[(phenyl)methylidene]-hydrazine, compounds 3(a-m) in the presence of anhydrous ZnCl2 afforded new heterocyclic compounds N-[2-(10Hphenothiazinyl) ethyl]-2-(phenyl)-4-oxo-1-iminothiazolidine, compounds 4(a-m). The later product on treatment with several selected substituted aromatic aldehydes in the presence of C2H5ONa undergoes Knoevenagel reaction to yield, compounds 5(a-m). The structure of compounds 1, 2, 3(a-m), 4(a-m) and 5(a-m) were confirmed by IR, 1H NMR, 13C NMR, FAB-Mass and chemical analysis. Compounds 5(a-m) have been screened for their antimicrobial and ant tubercular activities, displayed satisfactory results.